The good news about having worked with various versions of Windows for a long time is that I can usually manage to figure out how to fix things that go wrong after an OS upgrade. (Because things go wrong after an OS upgrade.) And Google is my friend.
Tonight's entertainment was that my Adobe Photoshop CS 5.1 wouldn't start. It turned out that there was a dialog about a bad Samsung monitor calibration that I had been able to click through in earlier versions and ignore that was now both present and completely inaccessible. The only thing to do was to kill Photoshop in Task Manager which did nothing for getting my work done.
But I applied my Google-fu and eventually:
Edited the registry
Ran the Windows Color Management software to try to delete the bad profile
Ran the Windows color calibration software
By the time I'd done the last of these things, Photoshop would run again.